Featured Project
voluba – Interactive registration of high-resolution volumes to 3D reference atlases
A common problem in high-resolution brain atlasing is spatial anchoring of volumes of interest from imaging experiments into the anatomical context of an ultrahigh-resolution reference model like BigBrain. This process requires efficient 3D interaction with image volumes at the Terabyte scale. We developed the interactive volumetric alignment tool voluba, which is implemented as a web service and offers an intuitive interactive workflow:
- Check out voluba under the following links. We are also happy to discuss with you on GitHub!
- voluba
- voluba documentation
- voluba on GitHub
![](images/featured/icon-5.png)
Select reference space and input volume
Choose between BigBrain, Allen mouse or Waxholm rat reference volumes, and upload your own input image after authenticating via EBRAINS or ORCID.
![](images/featured/icon-4.png)
Adjust the appearance of the input image
Customize contrast, brightness, colormaps, and intensity thresholds of the input image for optimal visualization.
![](images/featured/icon-3.png)
Interactive Alignment
Manipulate position and orientation of the input volume using the mouse pointer and adjust global parameters including voxel scaling and axis orientations to obtain a 3D similarity transformation.
![](images/featured/icon-2.png)
Refine With 3D Landmarks
Refine the alignment using interactive annotation of 3D landmark pairs to recalculate the transformation, with additional degrees of freedom including shearing.
![](images/featured/icon-1.png)
- Use The Results
- Save and reimport transformation and landmarks
- Import the result in other tools, such as ANTs
- Share a private URL to the anchored volume
- Open the anchored volume in the 3D atlas viewer siibra-explorer
![](images/featured/voluba.png)