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the major advantage of the BigBrain for our work is that the image data of the human brain are registered as a 3D volume at very high spatial resolution. Since the human brain is folded, any part of the cortical ribbon may be subjected to the geometrical effects of this folding, i.e. the cortex is obliquely or even tangentially sectioned at various sites in a 2D representation, e.g. in images of single microtome sections. This effect hampers the measurement of any cortical structure which is bound to the 3D columnar architecture of the cortex. In contrast, the BigBrain allows analyses in 3D, and thus has opened the door to many studies which would not be possible in 2D representations.
With HIBALL the partnership between two world-leading research institutions in computational neuroscience will provide an important platform for the scientists to conduct innovative, interdisciplinary, and complementary research in a rich and collaborative setting.
HIBALL assembles a team with world-leading expertise in neuroimaging, artificial intelligence, neuroscience and neuroinformatics, which complements well the team at Mila. The active participation of several PIs with ties to Mila is very exciting, and we anticipate this lab will further expand the collaboration between neuroscience and AI experts in the Montreal ecosystem, leading to cutting-edge discoveries in both fields.
HIBALL can build on a remarkable expertise and international reputation and will lead to high impact contributions in Human Brain Atlasing, Neuroinformatics, and Machine Learning.